Product Name :
BT18
Description:
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function.
CAS:
924811-53-0
Molecular Weight:
637.64
Formula:
C30H31F4N3O6S
Chemical Name:
2-(3-{4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl}-4-methoxybenzenesulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Smiles :
COC1=CC=C(C=C1N1CCN(CC1)C(=O)C1=CC=C(F)C=C1C(F)(F)F)S(=O)(=O)N1CC2=CC(OC)=C(C=C2CC1)OC
InChiKey:
QVIIZVVDZZHGCB-UHFFFAOYSA-N
InChi :
InChI=1S/C30H31F4N3O6S/c1-41-26-7-5-22(44(39,40)37-9-8-19-14-27(42-2)28(43-3)15-20(19)18-37)17-25(26)35-10-12-36(13-11-35)29(38)23-6-4-21(31)16-24(23)30(32,33)34/h4-7,14-17H,8-13,18H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function.|Product information|CAS Number: 924811-53-0|Molecular Weight: 637.64|Formula: C30H31F4N3O6S|Chemical Name: 2-(3-{4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl}-4-methoxybenzenesulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline|Smiles: COC1=CC=C(C=C1N1CCN(CC1)C(=O)C1=CC=C(F)C=C1C(F)(F)F)S(=O)(=O)N1CC2=CC(OC)=C(C=C2CC1)OC|InChiKey: QVIIZVVDZZHGCB-UHFFFAOYSA-N|InChi: InChI=1S/C30H31F4N3O6S/c1-41-26-7-5-22(44(39,40)37-9-8-19-14-27(42-2)28(43-3)15-20(19)18-37)17-25(26)35-10-12-36(13-11-35)29(38)23-6-4-21(31)16-24(23)30(32,33)34/h4-7,14-17H,8-13,18H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (156.{{Rotenone} medchemexpress|{Rotenone} Autophagy|{Rotenone} Technical Information|{Rotenone} Data Sheet|{Rotenone} supplier|{Rotenone} Autophagy} 83 mM; Need ultrasonic).{{Sulbactam} web|{Sulbactam} Bacterial|{Sulbactam} Technical Information|{Sulbactam} Formula|{Sulbactam} supplier|{Sulbactam} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23329650 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines. BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines. BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells.|Products are for research use only. Not for human use.|