Product Name :
Rabbit anti-NF2 Polyclonal Antibody
Synonym :
ACN; BANF; SCH
Host :
Rabbit
Species Reactivity:
Human
Specificity :
Predicted Reactivity:
Applications :
WB 1:500 – 1:2000IF 1:20 – 1:100
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-595 of human NF2 (NP_000259.1).
Concentration :
Purification :
Affinity purification
Clonality:
Polyclonal Antibody
Storage Temp.:
Store at -20 ℃Avoid freeze / that cycles
Research areas :
Background :
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
UniProt :
P35240
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym ACN; BANF; SCH |Host Rabbit |Species Reactivity Human |Applications WB 1:500 – 1:2000IF 1:20 – 1:100 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 19-595 of human NF2 (NP_000259.1). |Positive control HeLa,293T,HepG2 |Properties |Purification Affinity purification |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |Target |Background This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. |Cellular localization Cell projection,Cytoplasm,Cytoplasmic granule,Cytoplasmic side,Nucleus,Nucleus,Peripheral membrane protein,cytoskeleton,filopodium membrane,perinuclear region,ruffle membrane |UniProt P35240 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-NF2 Polyclonal Antibody
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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