About us

MPEG-1 is a standard for lossy compression of video and audio. It is designed to compress VHS-quality raw digital video and CD audio down to 1.5 Mbit/s without excessive quality loss, making video CDs, digital cable/satellite TV and digital audio broadcasting (DAB) possible. Prostaglandin E2 (PGE2) is the most abundant prostaglandin in the human body. It has a large number of biological actions that it exerts via four types of receptors, EP1– 4. MAPEG contains leukotriene C4 synthase and 5-lipoxygenase-activating protein as well as three glutathione transferases/peroxidases called microsomal glutathione transferase 1–3 (MGST1–3). Microsomal glutathione transferase 1 is the most well characterized for substrate specificity, kinetic mechanism, and three-dimensional structure (Holm et al., 2006) and, being the closest relative to mPGES-1 (38% identity), serves as a good model for generating hypotheses on structure function relationships. mPGES-1 has emerged as a potential target for the development of drugs for treatment of inflammation, pain, cancer, atherosclerosis, and stroke.