ar infiltration rate138,208,210,211 Physiologic adjustments Micro-disruption of BBB43,101,102,181,182,215 Reduction in P-gp activity43,101,102,181,182,215 Higher sensitivity to

ar infiltration rate138,208,210,211 Physiologic adjustments Micro-disruption of BBB43,101,102,181,182,215 Reduction in P-gp activity43,101,102,181,182,215 Higher sensitivity to cholinergic receptor45,46,216 PD consequences Elevated permeability of donepezil, galantamine and rivastigmine across BBB Elevated permeability…