The diverse parameters had been: the costs for activation of GRK by PKA_energetic (k61), dephosphorylation of GRK (k62), phosphorylation of VPAC2 by GRK (k63), dephosphorylation of VPAC2 (k64), phosphorylated VPAC2 receptor internalization (k42), insertion of new VPAC2 receptors (k70)

For minimal VIP concentrations (,,1 nM), the time system of simulated cAMP accumulation represented an exponential rise to some continuous-point out stage, whilst for increased concentrations (one nM) this accumulation…