Product Name :
DL-Homocysteine
Description:
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.
CAS:
454-29-5
Molecular Weight:
135.18
Formula:
C4H9NO2S
Chemical Name:
2-amino-4-sulfanylbutanoic acid
Smiles :
NC(CCS)C(O)=O
InChiKey:
FFFHZYDWPBMWHY-UHFFFAOYSA-N
InChi :
InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.|Product information|CAS Number: 454-29-5|Molecular Weight: 135.18|Formula: C4H9NO2S|Chemical Name: 2-amino-4-sulfanylbutanoic acid|Smiles: NC(CCS)C(O)=O|InChiKey: FFFHZYDWPBMWHY-UHFFFAOYSA-N|InChi: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 41.Anti-Mouse TCR gamma/delta Antibody Biological Activity 67 mg/mL (308.Cipargamin MedChemExpress 23 mM; Need ultrasonic).PMID:33305633 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM.|In Vivo:|DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus.|Products are for research use only. Not for human use.|