Nt of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Received: 14 July 2014 Accepted: 6 February7.8. 9.ten. 16.17.18. 19. 20. 21.22.23. 24. 25. 26.References 1. Boyle P, Ferlay J. Cancer incidence and mortality in Europe 2004. Ann Oncol. 2005;16(3):481?. 2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71?six. three. Parker C. Active Surveillance: towards a brand new paradigm within the management of early prostate cancer. Lancet Oncol. 2004;5:101?. 4. Loeb S, Vellekoop A, Ahmed HU, Catto J, Emberton M, Nam R, et al. Systematic Evaluation of Complications of Prostate Biopsy. Eur Urol. 2013;64:876?two. five. Schroder FH, Hugosson J, Roobol MJ, Tammela T, Ciatto S, Nelen V. Screening and prostate-cancer mortality inside a randomized European study. N Engl J Med. 2009;360:1320?. 6. Andriole GL, Crawford ED, Grubb RL, Buys S, Chia D, Church TR. Mortality final results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360:1310?.27.28. 29.Moyer VA. Screening for Prostate Cancer with Prostate-Specific HDAC8 supplier Antigen Testing: U.S. Preventive Solutions Process Force Recommendation Statement. Ann Intern Med. 2012;157:1?four. Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, Mason MD et al. Recommendations on Prostate Cancer. [uroweb.org/guideline/prostate-cancer/] Prostate Cancer Threat Management Programme: Guide No 1: Undertaking a transrectal ultrasound guided biopsy from the prostate, 2006. [ CaMK III Compound cancerscreening.nhs.uk/prostate/pcrmp01.pdf] National Institute for Well being and Care Excellence: Good Clinical Guideline 175, Prostate Cancer: Diagnosis and Remedy. January 2014. [https://nice. orguk/guidance/cg175] Rosario DJ, Lane JA, Metcalfe C, Donovan J, Doble A, Goodwin ML, et al. Short term outcomes of prostate biopsy in guys tested for cancer by PSA: A prospective evaluation inside the Protect study. BMJ. 2012;344:d7894. Wade J, Rosario DJ, Macefield RC, Avery KNL, Salter CE, Goodwin ML, et al. Psychological influence of prostate biopsy: physical symptoms, anxiety and depression. JCO. 2013;31(33):4235?1. Raaijmakers R, Kirkels WJ, Roobol MJ, Wildhagen MF, Schroder FH. Complication prices and threat variables of 5802 transrectal ultrasound-guided sextant biopsies of your prostate inside a population-based screening program. Urology. 2002;60:826?0. Djavan B, Waldert M, Zlotta A, Dobronski P, Seitz C, Remzi M, et al. Security and morbidity of initially and repeat transrectal ultrasound guided prostate needle biopsies: results of a prospective European prostate cancer detection study. J Urol. 2001;166:856?0. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiat Scand. 1983;67:361?0. Lane JA, Donovan JL, Davis M, Walsh E, Dedman D, Down L et al. Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study style and diagnostic and baseline benefits of the Protect randomised phase 3 trial. Lancet Oncol 2014. dx.doi.org/10.1016/S1470-2045 (14)70361-4. Avery KNL, Blazeby JM, Lane JA, Neal DE, Hamdy FC, Donovan JL. Decisionmaking about PSA Testing and Prostate Biopsies: A qualitative study embedded within a major care randomized trial. Eur Urol. 2008;53:1186?3. Glaser BG, Strauss AL. The discovery of grounded theory. Chicago: Aldine; 1967. Charmaz K. Constructing grounded theory: a practical guide by way of qualitative evaluation. London: Sage; 2006. QSR International Pty Ltd: QSR NVivo, version 8. 1999?000. Husson O,.

By mPEGS 1