Product Name :
PF-5006739
Description:
PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity.
CAS:
1293395-67-1
Molecular Weight:
419.45
Formula:
C22H22FN7O
Chemical Name:
4-[4-(4-fluorophenyl)-1-{1-[(1,2-oxazol-3-yl)methyl]piperidin-4-yl}-1H-imidazol-5-yl]pyrimidin-2-amine
Smiles :
NC1=NC(=CC=N1)C1=C(N=CN1C1CCN(CC2C=CON=2)CC1)C1C=CC(F)=CC=1
InChiKey:
XPWHRQHBPRSUAW-UHFFFAOYSA-N
InChi :
InChI=1S/C22H22FN7O/c23-16-3-1-15(2-4-16)20-21(19-5-9-25-22(24)27-19)30(14-26-20)18-6-10-29(11-7-18)13-17-8-12-31-28-17/h1-5,8-9,12,14,18H,6-7,10-11,13H2,(H2,24,25,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Irinotecan} MedChemExpress|{Irinotecan} Autophagy|{Irinotecan} Technical Information|{Irinotecan} In Vitro|{Irinotecan} manufacturer|{Irinotecan} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity.|Product information|CAS Number: 1293395-67-1|Molecular Weight: 419.45|Formula: C22H22FN7O|Chemical Name: 4-[4-(4-fluorophenyl)-1-{1-[(1,2-oxazol-3-yl)methyl]piperidin-4-yl}-1H-imidazol-5-yl]pyrimidin-2-amine|Smiles: NC1=NC(=CC=N1)C1=C(N=CN1C1CCN(CC2C=CON=2)CC1)C1C=CC(F)=CC=1|InChiKey: XPWHRQHBPRSUAW-UHFFFAOYSA-N|InChi: InChI=1S/C22H22FN7O/c23-16-3-1-15(2-4-16)20-21(19-5-9-25-22(24)27-19)30(14-26-20)18-6-10-29(11-7-18)13-17-8-12-31-28-17/h1-5,8-9,12,14,18H,6-7,10-11,13H2,(H2,24,25,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amylase} medchemexpress|{Amylase} Technical Information|{Amylase} In Vivo|{Amylase} supplier|{Amylase} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23805407 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|