Product Name :
trans-Chalcone
Description:
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity.
CAS:
614-47-1
Molecular Weight:
208.26
Formula:
C15H12O
Chemical Name:
(2E)-1,3-diphenylprop-2-en-1-one
Smiles :
O=C(/C=C/C1C=CC=CC=1)C1C=CC=CC=1
InChiKey:
DQFBYFPFKXHELB-VAWYXSNFSA-N
InChi :
InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SR9011} MedChemExpress|{SR9011} Vitamin D Related/Nuclear Receptor|{SR9011} Activator|{SR9011} Purity & Documentation|{SR9011} Description|{SR9011} custom synthesis}
Shelf Life:
≥12 months if stored properly.{{Evofosfamide} web|{Evofosfamide} Apoptosis|{Evofosfamide} Biological Activity|{Evofosfamide} In Vitro|{Evofosfamide} supplier|{Evofosfamide} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity.|Product information|CAS Number: 614-47-1|Molecular Weight: 208.26|Formula: C15H12O|Chemical Name: (2E)-1,3-diphenylprop-2-en-1-one|Smiles: O=C(/C=C/C1C=CC=CC=1)C1C=CC=CC=1|InChiKey: DQFBYFPFKXHELB-VAWYXSNFSA-N|InChi: InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23910527 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM. trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells. trans-Chalcone (20-80 μM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2. trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours. trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC20=30.23 μM; IC50=58.25 μM; IC80=98.03 μM). trans-Chalcone (48 h) has IC50s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity.|Products are for research use only. Not for human use.|